心血管疾病基础研究OCA对肥胖引起的心肌

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肥胖是心肌细胞凋亡、纤维化和心室肥大的主要原因，与肥大心肌病风险增加有关。奥贝胆酸（OCA）是脂质代谢、炎症、纤维化和代谢途径的关键调节剂。本研究旨在研究OCA对肥胖引起的心肌损伤的影响和机理，为OCA在心肌细胞中的保护作用提供了证据。

Protectiveeffectofobeticholicacidonobesity-induced

cardiomyopathy

ChaoLi,ShijunZhang,ZhiboGai,YunlunLi

OBJECTIVES

Obesityisamajorcontributortomyocardialcellapoptosis,fibrosisandventriclehypertrophy,andassociatedwiththeincreasedriskofhypertrophiccardiomyopathy.Obeticholicacid(OCA),afarnesoidXreceptoragonist,isakeyregulatoroflipidmetabolism,inflammatory,fibrosisandmetabolicpathways.ThisstudywasperformedtoinvestigatetheeffectandmechanismofOCAonobesity-inducedmyocardialinjury.

METHODS

C57Bl/6micewerefedwitha45%highfatdiet(HFD)orastandarddiet.Biochemicalparametersandmyocardialpathologicalchangeswereexamined.Energymetabolisminisolatedworkingheartusingradioactivewasalsotestedtorevealthemechanismofmyocardialinjury.Invitro,3Dcellculture,mitochondriadamageandATPproductionofC2C12cellsculturedwithpalmiticacid(PA)intheabsenceorpresenceofOCAweretested.

RESULTS

ThebodyweightofHFDC57Bl/6micehasincreasedby22.7%


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